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NeurogesX submitted a new drug

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application (NDA) for Qutenza to the U.S. NGSX), a biopharmaceutical company focused on developing and commercializing novel pain management therapies, today announced it will hold a conference call on at
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9:00 a.m. NGX-1998 has completed three Phase 1 studies and NeurogesX is currently evaluating the timing of entering Phase 2 development. Food and Drug Administration (FDA) in for PHN, which was accepted for filing by the FDA in December 2008. Safe Harbor Statement This contains forward-looking
chemist
statements for purposes of the Private Securities Litigation Reform Act of 1995 (the "Act").

PT) and ending on by dialing 1-877-660-6853 (USA) or 1-201-612-7415 (International), Account

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Number. To access the live web cast please visit the Investor Relations section on the corporate web site at. A replay of the webcast will also be available on the corporate website for one
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month, through. NGSX) is a biopharmaceutical company focused on developing and
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commercializing novel pain management therapies. A marketing NeurogesX is currently awaiting the European Commission's decision on the CHMP's opinion. Its initial focus is on chronic peripheral neuropathic pain, including postherpetic neuralgia (PHN), painful HIV-distal
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sensory polyneuropathy (HIV-DSP) and painful diabetic neuropathy (PDN). For further information regarding these and other risks related to NeurogesX' business, investors should consult NeurogesX' filings with the Securities and Exchange Commission.

Examples of such statements include, but are not limited to, the expected timing

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of the European
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Commission's decision on the CHMP's recommendation for approval of the MAA for Qutenza in the European Union; NeurogesX' plans to seek and timing to obtain a commercial partner for Qutenza in Europe; the expected benefits of NeurogesX' product
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candidates and its plans with regard to seeking potential development partners for its edik stage product pipeline. The company has evaluated these compounds in vitro and in lumbar spine pain relief vivo and is currently seeking development partners for these programs. Such statements are based on management's current expectations, but actual results
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may differ materially due to various risks and uncertainties, including, but not limited to; positive results in clinical trials may not be sufficient to obtain FDA or European regulatory approval; any regulatory approvals which are received may be limited to certain indications; NeurogesX' product candidates may have unexpected adverse side effects or inadequate therapeutic efficacy; physician
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or patient reluctance to use Qutenza
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or NGX-1998, if approved, or the inability of physicians to obtain sufficient reimbursement for such procedures; potential alternative therapies; maintaining adequate patent or trade secret protection without violating the intellectual property rights of others; and other difficulties or delays in, clinical development,
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obtaining regulatory approval, market acceptance and commercialization of NeurogesX' product candidates and the advantages of NeurogesX' product candidates over other pain therapies. NeurogesX disclaims any intent or obligation to update these forward-looking statements, and claims the protection of the Safe Harbor for forward-looking statements contained in the Act.

NeurogesX' frankie stage product pipeline includes pre-clinical compounds, which are prodrugs

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of acetaminophen and
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various opioids. PT) to discuss fourth quarter and year-end 2008 results and the European Medicines Agency's (EMEA) Committee for Medicinal Products for Human Use (CHMP) positive opinion recommending approval of Qutenza(TM) (formerly NGX-4010), for the treatment of peripheral neuropathic pain in non-diabetic adults either alone or in combination with
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other medicinal products for pain. A replay of the conference call
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will be available beginning at 12:00 p.m. NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin
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designed to treat pain associated with neuropathic pain conditions.

NeurogesX to Hold Conference Call to Discuss Fourth Quarter and Year-End 2008 Financial Results and European Regulatory Update Qutenza(TM) (NGX-4010) Receives Positive Committee Recommendation in European Union SAN MATEO, Calif., / - / -- NeurogesX, Inc. The conference call will be hosted by Kahlil DiTonno, President and Chief Executive Officer, and Regen Ghiglieri, Chief Financial Officer. To participate, please dial 1-877-407-0789 (USA) or 1-201-689-8562 (International).

NeurogesX' late stage product portfolio is led by its product candidate Qutenza, a dermal patch designed to manage pain associated with peripheral neuropathic pain conditions, that the Company believes offers significant advantages over other pain therapies.

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